Article
Tissue factor and PAR1 promote microbiota-induced intestinal vascular remodelling.
Nature - 11 Mar 2012
Reinhardt Christoph, Bergentall Mattias, Greiner Thomas U, Schaffner Florence, Ostergren-Lundén Gunnel, Petersen Lars C, Ruf Wolfram, Bäckhed Fredrik
Abstract excerpt
The gut microbiota is a complex ecosystem that has coevolved with host physiology. Colonization of germ-free (GF) mice with a microbiota promotes increased vessel density in the small intestine, but little is known about the mechanisms involved. Tissue factor (TF) is the membrane receptor that initiates the extrinsic coagulation pathway, and it promotes developmental and tumour angiogenesis. Here we show that the...
Topics
- Alleles
- Angiopoietin-1
- Animals
- Enterocytes
- Female
- Glycosylation
- Intestine, Small
- Mice
- Neovascularization, Physiologic
- Phosphorylation
- Protein Structure, Tertiary
- Receptor, PAR-1
- Receptor, PAR-2
- Signal Transduction