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Article

Cooperation of tissue factor cytoplasmic domain and PAR2 signaling in breast cancer development

23 Sept 2010

Abstract excerpt

Constitutive expression of tissue factor (TF) by cancer cells triggers local activation of the coagulation cascade and promotes breast cancer progression through cell signaling involving protease activated receptor (PAR)2. In human breast cancer, TF and PAR2 are up-regulated and TF cytoplasmic domain phosphorylation is correlated with relapse. Here we show that cancer cell PAR2 signaling promotes angiogenesis...

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Identifiers

PMID: 20861457
DOI: 10.1182/blood-2010-06-289314

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