Article

Tissue factor-dependent colitogenic CD4+ T cell thrombogenicity is regulated by activated protein C signalling

2024-04-20

Abstract excerpt

<h4>ABSTRACT</h4> Inflammatory bowel disease (IBD) patients experience up to 6-fold increased risk of venous thromboembolism (VTE) compared to the general population, although the mechanistic basis for this increased risk remains poorly defined. We found that colitogenic CD4 + T cells express tissue factor (TF) and promote rapid TF-dependent plasma thrombin generation in T cell-dependent calibrated automated thr...

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Literature Corpus work: de22bac3-3079-59d5-ab0b-08b717f420e2
DOI: 10.1101/2024.04.16.589774

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