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Article

Effects of the gut microbiota on placental angiogenesis and intrauterine growth in gnotobiotic mice

25 Jul 2025

Abstract excerpt

Environmental causes of intrauterine growth restriction (IUGR) remain poorly characterized. Here, we compare germ-free (GF) and conventionally raised (CONV-R) mice to assess the effects of the gut microbiota on placental/fetal development at embryonic day (E)11.5 (end of placentation) and E17.5 (near term). Pregnancy- and microbiota-associated changes in gene expression occur along the gut, including those...

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PMID: 40711921
DOI: 10.1073/pnas.2426341122

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