Article

Proteinase-Activated Receptor 1 Inhibition Alleviates Intestinal Fibrosis in Mice with Chronic Colitis

2024-01-09

Abstract excerpt

<title>Abstract</title> <p>Intestinal fibrosis is a serious complication of inflammatory bowel disease (IBD). Proteinase-activated receptor (PAR) 1 is a highly conserved G protein-coupled receptor that is relevant to IBD. We investigated the expression of PAR1 in the progression of intestinal fibrosis in human tissues and mice with chronic enteritis. We acquired intestinal biopsy samples from 6 patients with sten...

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Literature Corpus work: 7da6316f-7fd9-54c6-bbe0-766e1b6f7498
DOI: 10.21203/rs.3.rs-3823707/v1

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