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Article

Profilin-1 phosphorylation directs angiocrine expression and glioblastoma progression through HIF-1α accumulation.

Nature cell biology - 1 May 2014

Fan Yi, Potdar Alka A, Gong Yanqing, Eswarappa Sandeepa M, Donnola Shannon, Lathia Justin D, Hambardzumyan Dolores, Rich Jeremy N, Fox Paul L

Abstract excerpt

The tumour vascular microenvironment supports tumorigenesis not only by supplying oxygen and diffusible nutrients but also by secreting soluble factors that promote tumorigenesis. Here we identify a feedforward mechanism in which endothelial cells (ECs), in response to tumour-derived mediators, r...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24747440
DOI: 10.1038/ncb2954
PMCID: PMC4036069

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24747440-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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