Article
Association of single nucleotide polymorphisms of nicotinic acetylcholine receptor subunits with cervical neoplasia.
Life sciences - 27 Nov 2012
Calleja-Macias Itzel, Osann Kathryn, Remedios-Chan Mariana, Barrera-Saldana Hugo A, Illades-Aguiar Berenice, Anton-Culver Hoda, Chikova Anna K, Grando Sergei A, Bernard Hans-Ulrich
Abstract excerpt
AIMS: Cholinergic signaling, particularly in response to non-physiological ligands like nicotine, stimulates carcinogenesis of a variety of tissue types including epithelia of the cervix uteri. Cholinergic signaling is mediated by nicotinic acetylcholine receptors (nAChRs), which are pentamers formed by subsets of 16 nAChR subunits. Recent literature suggests that single nucleotide polymorphisms (SNPs) of some of...
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