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Investigation of the α9-nicotinic receptor single nucleotide polymorphisms induced oncogenic properties and molecular mechanisms in breast cancer.

Human molecular genetics - 8 Nov 2024

Liao You-Cheng, Wang Lu-Hai, Hung Mien-Chie, Cheng Tzu-Chun, Lin Ying-Chi, Chang Jungshan, Tu Shih-Hsin, Wu Chih-Hsiung, Yen Yun, Hsieh Yi-Chen, Chen Li-Ching, Ho Yuan-Soon

Abstract excerpt

α9-nAChR, a subtype of nicotinic acetylcholine receptor, is significantly overexpressed in female breast cancer tumor tissues compared to normal tissues. Previous studies have proposed that specific single nucleotide polymorphisms (SNPs) in the CHRNA9 (α9-nAChR) gene are associated with an increased risk of breast cancer in interaction with smoking. The study conducted a breast cancer risk assessment of the...

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Identifiers

PMID: 39251229
DOI: 10.1093/hmg/ddae132

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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