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Article

New associations of the genetic polymorphisms in nicotinic receptor genes with the risk of lung cancer.

Life sciences - 27 Nov 2012

Chikova Anna, Bernard Hans-Ulrich, Shchepotin Igor B, Grando Sergei A

Abstract excerpt

AIMS: Previous studies revealed association of lung cancer risk with single nucleotide polymorphisms (SNPs) in chromosome 15q25 region containing CHRNA5-CHRNA3-CHRNB4 nicotinic acetylcholine receptor (nAChR) subunit gene cluster. The genetic variations in other lung nAChRs remained unknown. In this study, we perform case-control analysis of CHRNA9 and CHRNA3 genes using 340 non-small cell lung cancer cases and...

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Share to Carcinoma, Non-Small-Cell Lung
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

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Share to Polymorphism, Single Nucleotide

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Source

Open in PubMed Open full text

Identifiers

PMID: 22280835
DOI: 10.1016/j.lfs.2011.12.023
PMCID: PMC3341501

Genes

CHRNA3
CHRNA9
CHRNA5
CHRNB4

Provenance

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