Article
Neuronal Acetylcholine Nicotinic Receptors as New Targets for Lung Cancer Treatment.
Current pharmaceutical design - 1 Jan 2016
Mucchietto Vanessa, Crespi Arianna, Fasoli Francesca, Clementi Francesco, Gotti Cecilia
Abstract excerpt
Lung cancer is the leading cause of cancer-related deaths worldwide. Smoking accounts for approximately 70% of the cases of non- small cell lung cancer (NSCLC) and 90% of the cases of small-cell lung cancer (SCLC), although some patients develop lung cancer without a history of smoking. Nicotine is the most active addictive component of tobacco smoke. It does not initiate tumorigenesis in humans and rodents, but...
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