Article
Neuropeptide S receptor gene (NPSR) and life events: G × E effects on anxiety sensitivity and its subdimensions.
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry - 1 Jan 2014
Klauke Benedikt, Deckert Jürgen, Zwanzger Peter, Baumann Christian, Arolt Volker, Pauli Paul, Reif Andreas, Domschke Katharina
Abstract excerpt
OBJECTIVES: The pathogenesis of anxiety is assumed to be interactively influenced by genetic and environmental factors. Thus, a gene-environment interaction (G × E) study of the neuropeptide S receptor gene (NPSR) A/T polymorphism (rs324981) and life events was conducted with respect to anxiety sensitivity (AS) as an intermediate phenotype of anxiety disorders. METHODS: A sample of 475 healthy German subjects was...
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