Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interaction between FKBP5 variability and recent life events in the anxiety spectrum: Evidence for the differential susceptibility model.

PloS one - 1 Jan 2018

Pérez-Pérez Beatriz, Cristóbal-Narváez Paula, Sheinbaum Tamara, Kwapil Thomas R, Ballespí Sergi, Peña Elionora, de Castro-Catala Marta, Riba Maria Dolors, Rosa Araceli, Barrantes-Vidal Neus

Abstract excerpt

BACKGROUND: Gene-environment interaction (GxE) research has highlighted the importance of investigating the FK506 binding protein 51 (FKBP5) gene as a sensitivity gene. However, previous GxE studies with FKBP5 have not measured the full environmental spectrum or applied statistical tests to discern whether the GxE interaction fits better with the differential-susceptibility or diathesis-stress hypotheses. This...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anxiety
Share to Depression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Models, Theoretical

Share to Neuroticism

Share to Psychiatric Status Rating Scales

Share to Stress, Psychological

Share to Tacrolimus Binding Proteins

Share to Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 29466454
DOI: 10.1371/journal.pone.0193044
PMCID: PMC5821376

Genes

FKBP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interaction between FKBP5 variability and recent life events in the anxiety spectrum: Evidence for the differential susceptibility model.PMID 29466454Read ↗

Gene–environment interactions at the <i><scp>FKBP5</scp></i> locus: sensitive periods, mechanisms and pleiotropismSemantic proximity Read ↗

Understanding the Molecular Mechanisms Underpinning Gene by Environment Interactions in Psychiatric Disorders: The FKBP5 Model.Semantic proximity Read ↗

Three-way interaction effects of early life stress, positive parenting and FKBP5 in the development of depressive symptoms in a general population.Semantic proximity Read ↗

Schizophrenia in the Spectrum of Gene-Stress Interactions: The FKBP5 ExampleSemantic proximity Read ↗

Gene-Stress-Epigenetic Regulation of FKBP5: Clinical and Translational Implications.Semantic proximity Read ↗

Associations between the FKBP5 haplotype, exposure to violence and anxiety in females.Semantic proximity Read ↗

The rs1360780 Variant of FKBP5: Genetic Variation, Epigenetic Regulation, and Behavioral PhenotypesSemantic proximity Read ↗

FKBP5 polymorphisms moderate the influence of adverse life events on the risk of anxiety and depressive disorders in preschool children.Semantic proximity Read ↗

The Role of FKBP5 in Mood Disorders: Action of FKBP5 on Steroid Hormone Receptors Leads to Questions About its Evolutionary ImportanceSemantic proximity Read ↗

Interaction between early-life stress and FKBP5 gene variants in major depressive disorder and post-traumatic stress disorder: A systematic review and meta-analysis.Semantic proximity Read ↗

Role of allelic variants of FK506-binding protein 51 (FKBP5) gene in the development of anxiety disorders.Semantic proximity Read ↗

Interaction of FKBP5 gene variants and adverse life events in predicting depression onset: results from a 10-year prospective community study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.