Genetic sensitivity to the environment moderates the impact of positive and negative childhood experiences on psychological adjustment "for good and for bad".

doi:10.1192/j.eurpsy.2026.10176

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Article

Genetic sensitivity to the environment moderates the impact of positive and negative childhood experiences on psychological adjustment "for good and for bad".

European psychiatry : the journal of the Association of European Psychiatrists - 31 Mar 2026

Torrecilla Pilar, Lavín Valeria, Arias-Magnasco Angelo, Danae Lin Bochao, Menne-Lothmann Claudia, Decoster Jeroen, van Winkel Ruud, Collip Dina, Delespaul Philippe, De Hert Marc, Derom Catherine, Thiery Every, Jacobs Nele, van Os Jim, Rutten Bart, Guloksuz Sinan, Barrantes-Vidal Neus

Abstract excerpt

BACKGROUND: The vulnerability-stress framework guiding gene-environment interaction (GxE) research overlooks the role of positive experiences. The Differential Susceptibility (DS) model offers a broader perspective, suggesting that individuals vary in sensitivity to both negative and positive environments. This study aimed at replicating previous DS research by examining interactions between polygenic scores for...

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Identifiers

PMID: 41913453
DOI: 10.1192/j.eurpsy.2026.10176
PMCID: PMC13122527

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