Article
Serotonin transporter gene and childhood trauma--a G × E effect on anxiety sensitivity.
Depression and anxiety - 21 Dec 2011
Klauke Benedikt, Deckert Jürgen, Reif Andreas, Pauli Paul, Zwanzger Peter, Baumann Christian, Arolt Volker, Glöckner-Rist Angelika, Domschke Katharina
Abstract excerpt
BACKGROUND: Genetic factors and environmental factors are assumed to interactively influence the pathogenesis of anxiety disorders. Thus, a gene-environment interaction (G × E) study was conducted with respect to anxiety sensitivity (AS) as a promising intermediate phenotype of anxiety disorders. METHOD: Healthy subjects (N = 363) were assessed for AS, childhood maltreatment (Childhood Trauma Questionnaire), and...
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