Genetic Susceptibility to the Environment Moderates the Impact of Childhood Experiences on Psychotic, Depressive, and Anxiety Dimensions.

doi:10.1093/schbul/sbad130

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Genetic Susceptibility to the Environment Moderates the Impact of Childhood Experiences on Psychotic, Depressive, and Anxiety Dimensions.

Schizophrenia bulletin - 4 Mar 2025

Barrantes-Vidal Neus, Torrecilla Pilar, Mas-Bermejo Patricia, Papiol Sergi, Bakermans-Kranenburg Marian J, van IJzendoorn Marinus H, Jolicoeur-Martineau Alexia, Kwapil Thomas R, Rosa Araceli

Abstract excerpt

BACKGROUND AND HYPOTHESIS: Gene-by-environment (GxE) studies in psychosis have exclusively focused on negative exposures. However, evidence supports the resilience-enhancing effect of positive factors on psychosis outcome. The Differential Susceptibility (DS) model proposes that common genetic variants may confer not only disproportionate responsiveness to negative environments, but also greater sensitivity to...

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Topics

Humans
Psychotic Disorders
Gene-Environment Interaction
Male
Female

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Young Adult

Adverse Childhood Experiences

Genetic Predisposition to Disease

Adult

Anxiety

Adolescent

Depression

Multifactorial Inheritance

Adult Survivors of Child Adverse Events

Anxiety Disorders

Schizotypal Personality Disorder

Source

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Identifiers

PMID: 40037819
DOI: 10.1093/schbul/sbad130
PMCID: PMC11879581

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