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Article

Genomic regions associated with multiple sclerosis are active in B cells.

PloS one - 1 Jan 2012

Disanto Giulio, Sandve Geir Kjetil, Berlanga-Taylor Antonio J, Morahan Julia M, Dobson Ruth, Giovannoni Gavin, Ramagopalan Sreeram V

Abstract excerpt

More than 50 genomic regions have now been shown to influence the risk of multiple sclerosis (MS). However, the mechanisms of action, and the cell types in which these associated variants act at the molecular level remain largely unknown. This is especially true for associated regions containing no known genes. Given the evidence for a role for B cells in MS, we hypothesized that MS associated genomic regions...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22396755
DOI: 10.1371/journal.pone.0032281
PMCID: PMC3292555

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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