Article
Genome-wide association studies in multiple sclerosis: lessons and future prospects.
Briefings in functional genomics - 1 Mar 2011
Kemppinen Anu, Sawcer Stephen, Compston Alastair
Abstract excerpt
Multiple sclerosis (MS) is an inflammatory neurodegenerative disease with complex aetiology. A haplotype within the major histocompatibility region is the major risk factor for MS, but despite clear evidence for a genetic component additional risk variants were not identified until the recent advent of genome-wide association studies (GWAS). At present, 10 GWAS have been conducted in MS, and together with...
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