Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Enhanced astrocyte responses are driven by a genetic risk allele associated with multiple sclerosis

11 Dec 2018

Abstract excerpt

Abstract Epigenetic annotation studies of genetic risk variants for multiple sclerosis (MS) implicate dysfunctional lymphocytes in MS susceptibility; however, the role of central nervous system (CNS) cells remains unclear. We investigated the effect of the risk variant, rs7665090 G , located near NFKB1 , on astrocytes. We demonstrated that chromatin is accessible at the risk locus, a prerequisite for its impact...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related molecular mechanisms research
Share to Cytokine Signaling Pathways and Interactions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Multiple Sclerosis Research Studies

Source

Identifiers

PMID: 30559390
DOI: 10.1038/s41467-018-07785-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Enhanced astrocyte responses are driven by a genetic risk allele associated with multiple sclerosisPMID 30559390Read ↗

Enhanced Astrocyte Responses are Driven by a Genetic Risk Allele Associated with Multiple SclerosisSemantic proximity Read ↗

Integration of epigenetic and genetic profiles identifies multiple sclerosis disease-critical cell types and genes.Semantic proximity Read ↗

GWAS highlights the neuronal contribution to multiple sclerosis susceptibilitySemantic proximity Read ↗

GWAS highlights the neuronal contribution to multiple sclerosis susceptibilitySemantic proximity Read ↗

DNA methylation changes in glial cells of the normal-appearing white matter in Multiple Sclerosis patientsSemantic proximity Read ↗

DNA methylation changes in glial cells of the normal-appearing white matter in Multiple Sclerosis patientsSemantic proximity Read ↗

The Multiple Sclerosis Genomic Map: Role of peripheral immune cells and resident microglia in susceptibilitySemantic proximity Read ↗

Spatial cell type mapping of multiple sclerosis lesionsSemantic proximity Read ↗

Oligodendroglia as functional effectors of Multiple Sclerosis risk variantsSemantic proximity Read ↗

Genome-wide association studies in multiple sclerosis: lessons and future prospects.Semantic proximity Read ↗

Dissection of multiple sclerosis genetics identifies B and CD4+ T cells as driver cell subsetsSemantic proximity Read ↗

Genomic regions associated with multiple sclerosis are active in B cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.