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Article

The BDNF Val66Met polymorphism impairs synaptic transmission and plasticity in the infralimbic medial prefrontal cortex.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Feb 2012

Pattwell Siobhan S, Bath Kevin G, Perez-Castro Rosalia, Lee Francis S, Chao Moses V, Ninan Ipe

Abstract excerpt

The brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is a common human single nucleotide polymorphism (SNP) that affects the regulated release of BDNF, and has been implicated in affective disorders and cognitive dysfunction. A decreased activation of the infralimbic medial prefrontal cortex (IL-mPFC), a brain region critical for the regulation of affective behaviors, has been described in BDNF(Met)...

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Source

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Identifiers

PMID: 22396415
DOI: 10.1523/JNEUROSCI.5205-11.2012
PMCID: PMC3532006

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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