Article
Identification of BDNF sensitive electrophysiological markers of synaptic activity and their structural correlates in healthy subjects using a genetic approach utilizing the functional BDNF Val66Met polymorphism.
PloS one - 1 Jan 2014
Soltész Fruzsina, Suckling John, Lawrence Phil, Tait Roger, Ooi Cinly, Bentley Graham, Dodds Chris M, Miller Sam R, Wille David R, Byrne Misha, McHugh Simon M, Bellgrove Mark A, Croft Rodney J, Lu Bai, Bullmore Edward T, Nathan Pradeep J
Abstract excerpt
Increasing evidence suggests that synaptic dysfunction is a core pathophysiological hallmark of neurodegenerative disorders. Brain-derived neurotropic factor (BDNF) is key synaptogenic molecule and targeting synaptic repair through modulation of BDNF signalling has been suggested as a potential drug discovery strategy. The development of such "synaptogenic" therapies depend on the availability of BDNF sensitive...
Topics
- Adult
- Brain
- Brain-Derived Neurotrophic Factor
- Electroencephalography
- Female
- Genotype
- Healthy Volunteers
- Humans
- Magnetic Resonance Imaging