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Article

Effects of TET2 mutations on DNA methylation in chronic myelomonocytic leukemia.

Epigenetics - 1 Feb 2012

Yamazaki Jumpei, Taby Rodolphe, Vasanthakumar Aparna, Macrae Trisha, Ostler Kelly R, Shen Lanlan, Kantarjian Hagop M, Estecio Marcos R, Jelinek Jaroslav, Godley Lucy A, Issa Jean-Pierre J

Abstract excerpt

TET2 enzymatically converts 5-methyl-cytosine to 5-hydroxymethyl-cytosine, possibly leading to loss of DNA methylation. TET2 mutations are common in myeloid leukemia and were proposed to contribute to leukemogenesis through DNA methylation. To expand on this concept, we studied chronic myelomonocytic leukemia (CMML) samples. TET2 missense or nonsense mutations were detected in 53% (16/30) of patients. In...

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Share to 5-Methylcytosine
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukemia, Myelomonocytic, Chronic

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Source

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Identifiers

PMID: 22395470
DOI: 10.4161/epi.7.2.19015
PMCID: PMC3335912

Genes

TET2
AIM2
IDH1
IDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Effects of TET2 mutations on DNA methylation in chronic myelomonocytic leukemia.PMID 22395470Read ↗

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