Article
TET2 mutations are associated with specific 5-methylcytosine and 5-hydroxymethylcytosine profiles in patients with chronic myelomonocytic leukemia.
PloS one - 1 Jan 2012
Pérez Cristina, Martínez-Calle Nicolas, Martín-Subero José Ignacio, Segura Victor, Delabesse Eric, Fernandez-Mercado Marta, Garate Leire, Alvarez Sara, Rifon José, Varea Sara, Boultwood Jacqueline, Wainscoat James S, Cruz Cigudosa Juan, Calasanz María José, Cross Nicholas C P, Prósper Felipe, Agirre Xabier
Abstract excerpt
Chronic myelomonocytic leukemia (CMML) has recently been associated with a high incidence of diverse mutations in genes such as TET2 or EZH2 that are implicated in epigenetic mechanisms. We have performed genome-wide DNA methylation arrays and mutational analysis of TET2, IDH1, IDH2, EZH2 and JAK2 in a group of 24 patients with CMML. 249 genes were differentially methylated between CMML patients and controls....
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