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Article

Association between WWOX/MAF variants and dementia-related neuropathologic endophenotypes.

Neurobiology of aging - 1 Mar 2022

Dugan Adam J, Nelson Peter T, Katsumata Yuriko, Shade Lincoln M P, Teylan Merilee A, Boehme Kevin L, Mukherjee Shubhabrata, Kauwe John S K, Hohman Timothy J, Schneider Julie A, Fardo David W

Abstract excerpt

The genetic locus containing the WWOX and MAF genes was implicated as a clinical Alzheimer's disease (AD) risk locus in two recent large meta-analytic genome wide association studies (GWAS). In a prior GWAS, we identified a variant in WWOX as a suggestive risk allele for hippocampal sclerosis. We hypothesized that the WWOX/MAF locus may be preferentially associated with non-plaque- and non-tau-related...

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PMID: 34852950
DOI: 10.1016/j.neurobiolaging.2021.10.011
PMCID: PMC8761217

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