Article
Job-related exhaustion risk variant in UST is associated with dementia and DNA methylation.
Scientific reports - 13 Jun 2024
Sulkava Sonja, Haukka Jari, Kaivola Karri, Doagu Fatma, Lahtinen Alexandra, Kantojärvi Katri, Pärn Kalle, Palta Priit, Myllykangas Liisa, Sulkava Raimo, Laatikainen Tiina, Tienari Pentti J, Paunio Tiina
Abstract excerpt
Previous genome-wide association and replication study for job-related exhaustion indicated a risk variant, rs13219957 in the UST gene. Epidemiological studies suggest connection of stress-related conditions and dementia risk. Therefore, we first studied association of rs13219957 and register-based incident dementia using survival models in the Finnish National FINRISK study surveys (N = 26,693). The AA genotype...
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