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Article

A hypermorphic antioxidant response element is associated with increased MS4A6A expression and Alzheimer's disease.

Redox biology - 1 Apr 2018

Lacher Sarah E, Alazizi Adnan, Wang Xuting, Bell Douglas A, Pique-Regi Roger, Luca Francesca, Slattery Matthew

Abstract excerpt

Late onset Alzheimer's disease (AD) is a multifactorial disorder, with AD risk influenced by both environmental and genetic factors. Recent genome-wide association studies (GWAS) have identified genetic loci associated with increased risk of developing AD. The MS4A (membrane-spanning 4-domains subfamily A) gene cluster is one of the most significant loci associated with AD risk, and MS4A6A expression is...

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Identifiers

PMID: 29179108
DOI: 10.1016/j.redox.2017.10.018
PMCID: PMC5705802

Genes

NRF1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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