Article
Genetic association and interaction analysis of USF1 and APOA5 on lipid levels and atherosclerosis.
Arteriosclerosis, thrombosis, and vascular biology - 1 Feb 2010
Laurila Pirkka-Pekka, Naukkarinen Jussi, Kristiansson Kati, Ripatti Samuli, Kauttu Tuuli, Silander Kaisa, Salomaa Veikko, Perola Markus, Karhunen Pekka J, Barter Philip J, Ehnholm Christian, Peltonen Leena
Abstract excerpt
OBJECTIVE: USF1 is a ubiquitous transcription factor governing the expression of numerous genes of lipid and glucose metabolism. APOA5 is a well-established candidate gene regulating triglyceride (TG) levels and has been identified as a downstream target of upstream stimulatory factor. No detailed studies about the effect of APOA5 on atherosclerotic lesion formation have been conducted, nor has its potential...
Topics
- Adult
- Aorta, Abdominal
- Aortic Diseases
- Apolipoprotein A-V
- Apolipoproteins A
- Atherosclerosis
- Australia
- Autopsy
- Cholesterol, HDL
- Cholesterol, LDL