Article
Identification of hippocampus-related candidate genes for Alzheimer's disease.
Annals of neurology - 1 Apr 2005
Taguchi Keiko, Yamagata Hidehisa D, Zhong Wangtao, Kamino Kouzin, Akatsu Hiroyasu, Hata Ryuji, Yamamoto Takayuki, Kosaka Kenji, Takeda Masatoshi, Kondo Ikuko, Miki Tetsuro
Abstract excerpt
Alzheimer's disease (AD) is a complex multifactorial disease in which many genetic and environmental factors are involved. We performed an association study using 376 AD patients and 376 control subjects. We studied 35 single nucleotide polymorphisms in 35 genes that were significantly downregulated or upregulated only in the AD hippocampus compared with control and found that 9 single nucleotide polymorphisms...
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