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Article

Hypothalamic-pituitary-adrenal axis genetic variation and early stress moderates amygdala function.

Psychoneuroendocrinology - 1 Jun 2017

Di Iorio Christina R, Carey Caitlin E, Michalski Lindsay J, Corral-Frias Nadia S, Conley Emily Drabant, Hariri Ahmad R, Bogdan Ryan

Abstract excerpt

Early life stress may precipitate psychopathology, at least in part, by influencing amygdala function. Converging evidence across species suggests that links between childhood stress and amygdala function may be dependent upon hypothalamic-pituitary-adrenal (HPA) axis function. Using data from college-attending non-Hispanic European-Americans (n=308) who completed the Duke Neurogenetics Study, we examined whether...

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Source

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Identifiers

PMID: 28364727
DOI: 10.1016/j.psyneuen.2017.03.016
PMCID: PMC5685810

Genes

CRHR1
FKBP5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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