Single-nucleotide polymorphisms in corticotropin releasing hormone receptor 1 gene (CRHR1) are associated with quantitative trait of event-related potential and alcohol dependence.

doi:10.1111/j.1530-0277.2010.01173.x

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Article

Single-nucleotide polymorphisms in corticotropin releasing hormone receptor 1 gene (CRHR1) are associated with quantitative trait of event-related potential and alcohol dependence.

Alcoholism, clinical and experimental research - 1 Jun 2010

Chen Andrew C H, Manz Niklas, Tang Yongqiang, Rangaswamy Madhavi, Almasy Laura, Kuperman Samuel, Nurnberger John, O'Connor Sean J, Edenberg Howard J, Schuckit Marc A, Tischfield Jay, Foroud Tatiana, Bierut Laura J, Rohrbaugh John, Rice John P, Goate Alison, Hesselbrock Victor, Porjesz Bernice

Abstract excerpt

BACKGROUND: Endophenotypes reflect more proximal effects of genes than diagnostic categories, hence providing a more powerful strategy in searching for genes involved in complex psychiatric disorders. There is strong evidence suggesting the P3 amplitude of the event-related potential (ERP) as an endophenotype for the risk of alcoholism and other disinhibitory disorders. Recent studies demonstrated a crucial role...

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Identifiers

PMID: 20374216
DOI: 10.1111/j.1530-0277.2010.01173.x
PMCID: PMC3248053

Genes

CRHR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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