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Article

MicroRNA-21 Knockout Exacerbates Angiotensin II-Induced Thoracic Aortic Aneurysm and Dissection in Mice With Abnormal Transforming Growth Factor-β-SMAD3 Signaling.

Arteriosclerosis, thrombosis, and vascular biology - 1 May 2018

Huang Xiaofan, Yue Zhang, Wu Jia, Chen Jiuling, Wang Sihua, Wu Jie, Ren Linyun, Zhang Anchen, Deng Peng, Wang Ke, Wu Chuangyan, Ding Xiangchao, Ye Ping, Xia Jiahong

Abstract excerpt

OBJECTIVE: Thoracic aortic aneurysm and dissection (TAAD) are severe vascular conditions. Dysfunctional transforming growth factor-β (TGF-β) signaling in vascular smooth muscle cells and elevated angiotensin II (AngII) levels are implicated in the development of TAAD. In this study, we investigated whether these 2 factors lead to TAAD in a mouse model and explored the possibility of using microRNA-21 (miR-21) for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to JNK Mitogen-Activated Protein Kinases

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Source

Identifiers

PMID: 29519942
DOI: 10.1161/ATVBAHA.117.310694

Genes

SMAD3
SMAD7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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