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Article

Cardiovascular phenotype in Smad3 deficient mice with renovascular hypertension.

PloS one - 1 Jan 2017

Kashyap Sonu, Warner Gina, Hu Zeng, Gao Feng, Osman Mazen, Al Saiegh Yousif, Lien Karen R, Nath Karl, Grande Joseph P

Abstract excerpt

Renovascular hypertension (RVH) has deleterious effects on both the kidney and the heart. TGF-β signaling through Smad3 directs tissue fibrosis in chronic injury models. In the 2-kidney 1-clip (2K1C) model of RVH, employing mice on the 129 genetic background, Smad3 deficiency (KO) protects the stenotic kidney (STK) from development of interstitial fibrosis. However, these mice have an increased incidence of...

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Share to Cardiovascular System
Share to Genes, ras
Share to Matrix Metalloproteinase 9

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred C57BL

Share to Mice, Knockout

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Share to Real-Time Polymerase Chain Reaction

Share to Smad3 Protein

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Identifiers

PMID: 29073282
DOI: 10.1371/journal.pone.0187062
PMCID: PMC5658153

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