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Article

Lysine residue at position 22 of the AID protein regulates its class switch activity.

PloS one - 1 Jan 2012

Geisberger Roland, Huemer Michael, Gassner Franz J, Zaborsky Nadja, Egle Alexander, Greil Richard

Abstract excerpt

BACKGROUND: Activation induced deaminase (AID) mediates class switch recombination and somatic hypermutation of immunoglobulin (Ig) genes in germinal centre B cells. In order to regulate its specific activity and as a means to keep off-target mutations low, several mechanisms have evolved, including binding to specific cofactors, phosphorylation and destabilization of nuclear AID protein. Although ubiquitination...

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Share to AICDA (Activation-Induced Cytidine Deaminase)

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22363466
DOI: 10.1371/journal.pone.0030667
PMCID: PMC3282692

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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