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Article

Modelling of HLA-DQ2 and its interaction with gluten peptides to explain molecular recognition in celiac disease.

Journal of molecular graphics & modelling - 1 Apr 2005

Costantini Susan, Rossi Mauro, Colonna Giovanni, Facchiano Angelo M

Abstract excerpt

Celiac disease (CD) is sustained by abnormal intestinal mucosal T-cell response to gluten and it is strongly associated with HLA class II molecules encoded by DQA1*0501/DQB1*02 (DQ2) or DQA1*03/DQB1*0302 (DQ8). The in vitro stimulatory activity of gliadin increases after treatment with tissue transglutaminase (tTG) which catalyses the deamidation of specific residues of glutamine to glutamate that can serve as...

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Source

Identifiers

PMID: 15781184
DOI: 10.1016/j.jmgm.2004.12.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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