Article
Structure of celiac disease-associated HLA-DQ8 and non-associated HLA-DQ9 alleles in complex with two disease-specific epitopes.
International immunology - 1 Aug 2000
Moustakas A K, van de Wal Y, Routsias J, Kooy Y M, van Veelen P, Drijfhout J W, Koning F, Papadopoulos G K
Abstract excerpt
The association of celiac disease (CD) with HLA-DQ2 and HLA-DQ8 is indicative of preferential mucosal T cell recognition of gluten fragments bound to either DQ allele. We have recently identified two gluten-derived, HLA-DQ8-restricted T cell stimulatory peptides, one each from gliadin and glutenin, recognized by specific T cell clones derived from the small intestine of CD patients. We have now performed...
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