Article
HLA-DQ2.5 genes associated with celiac disease risk are preferentially expressed with respect to non-predisposing HLA genes: Implication for anti-gluten T cell response.
Journal of autoimmunity - 1 Jun 2016
Pisapia Laura, Camarca Alessandra, Picascia Stefania, Bassi Virginia, Barba Pasquale, Del Pozzo Giovanna, Gianfrani Carmen
Abstract excerpt
HLA genes represent the main risk factor in autoimmune disorders. In celiac disease (CD), the great majority of patients carry the HLA DQA1*05 and DQB1*02 alleles, both of which encode the DQ2.5 molecule. The formation of complexes between DQ2.5 and gluten peptides on antigen-presenting cells (APCs) is necessary to activate pathogenic CD4(+) T lymphocytes. It is widely accepted that the DQ2.5 genes establish the...
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