Structural Insights into HLA-DQ-Associated Susceptibility to Celiac Disease Through an Integrated Genetic and In Silico Approach in a Sardinian Population.

Abstract excerpt

BACKGROUND: Celiac disease (CD) is a multifactorial autoimmune disorder strongly associated with specific HLA class II molecules, particularly HLA-DQ-encoding haplotypes. Although the genetic contribution of these loci is well established, the structural features accompanying allele-specific disease susceptibility remain incompletely explored. METHODS: In this study, molecular HLA typing was integrated with in...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Case-Control Studies
• Share to Celiac Disease