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Article

Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in celiac disease

12 Mar 2004

Abstract excerpt

Celiac disease, also known as celiac sprue, is a gluten-induced autoimmune-like disorder of the small intestine, which is strongly associated with HLA-DQ2. The structure of DQ2 complexed with an immunogenic epitope from gluten, QLQPFPQPELPY, has been determined to 2.2-A resolution by x-ray crystallography. The glutamate at P6, which is formed by tissue transglutaminase-catalyzed deamidation, is an important...

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PMID: 15020763
DOI: 10.1073/pnas.0306885101

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