Article
BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner.
Cell - 12 Jul 1991
Pendergast A M, Muller A J, Havlik M H, Maru Y, Witte O N
Abstract excerpt
BCR-ABL is a chimeric oncogene implicated in the pathogenesis of Philadelphia chromosome-positive human leukemias. BCR first exon sequences specifically activate the tyrosine kinase and transforming potential of BCR-ABL. We have tested the hypothesis that activation of BCR-ABL may involve direct...
Topics
- Amino Acid Sequence
- Animals
- Binding Sites
- Cell Line
- Cell Transformation, Neoplastic
- Exons
- Fusion Proteins, bcr-abl
- Genes, abl
- Genetic Variation
- Humans
- Insecta
- Molecular Sequence Data