Article
Tyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factors.
The Journal of biological chemistry - 24 Oct 2003
Araki Toshiyuki, Nawa Hiroyuki, Neel Benjamin G
Abstract excerpt
The protein-tyrosine phosphatase Shp2 is required for normal activation of the ERK mitogen-activated protein kinase in multiple receptor tyrosine kinase signaling pathways. In fibroblasts, Shp2 undergoes phosphorylation at two C-terminal tyrosyl residues in response to some (fibroblast growth factor and platelet-derived growth factor (PDGF)) but not all (epidermal growth factor and insulin-like growth factor)...
Topics
- 3T3 Cells
- Adaptor Proteins, Signal Transducing
- Animals
- Binding Sites
- Enzyme Activation
- Epidermal Growth Factor
- Fibroblast Growth Factors
- GRB2 Adaptor Protein
- Growth Substances
- Intracellular Signaling Peptides and Proteins
- Mice
- Mitogen-Activated Protein Kinases
- Mutation