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Article

Reconstitution of interactions between the Src tyrosine kinases and Ras GTPase-activating protein using a baculovirus expression system.

The Journal of biological chemistry - 5 Jun 1992

Park S, Marshall M S, Gibbs J B, Jove R

Abstract excerpt

Ras GTPase-activating protein (GAP) has been implicated in mitogenic signal transduction downstream of oncogenic and receptor tyrosine kinases. Previous studies have suggested that GAP is phosphorylated by oncogenic viral Src (v-Src) and that GAP is associated with a complex containing normal cel...

Topics

Baculoviridae
Chromosome Deletion
GTPase-Activating Proteins
Gene Expression
Genes, Viral
Genetic Vectors
Mutation
Oncogene Protein pp60(v-src)
Phosphorylation
Protein-Tyrosine Kinases
Proteins
Proto-Oncogene Proteins pp60(c-src)

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

ras GTPase-Activating Proteins

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PMID: 1375945

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1375945-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Reconstitution of interactions between the Src tyrosine kinases and Ras GTPase-activating protein using a baculovirus expression system.PMID 1375945Read ↗

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Biochemical characterization of baculovirus-expressed rap1A/Krev-1 and its regulation by GTPase-activating proteins.Semantic proximity Read ↗

A new strategy to produce active human Src from bacteria for biochemical study of its regulation.Semantic proximity Read ↗

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Suppression of c-ras transformation by GTPase-activating protein.Semantic proximity Read ↗

SH3 domains specifically regulate kinase activity of expressed Src family proteins.Semantic proximity Read ↗

Regulation of ras p21 by GTPase activating proteins.Semantic proximity Read ↗

The amino-terminal 14 amino acids of v-src can functionally replace the extracellular and transmembrane domains of v-erbB.Semantic proximity Read ↗

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Autophosphorylation of purified c-Src at its primary negative regulation site.Semantic proximity Read ↗

Autophosphorylation is required for high kinase activity and efficient transformation ability of proteins encoded by host range alleles of v-src.Semantic proximity Read ↗

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