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Article

Non-canonical dynamic mechanisms of interaction between the p66Shc protein and Met receptor.

The Biochemical journal - 1 Jun 2016

Landry Mélissa, Pomerleau Véronique, Saucier Caroline

Abstract excerpt

Met receptor tyrosine kinase (RTK) is known to bind to the three distinct protein isoforms encoded by the ShcA (Shc) gene. Structure-function studies have unveiled critical roles for p52Shc-dependent signalling pathways in Met-regulated biological functions. The molecular basis of the interaction between the Met and p52Shc proteins is well-defined, but not for the longest protein isoform, p66Shc. In the present...

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Identifiers

PMID: 27048591
DOI: 10.1042/BCJ20160249
PMCID: PMC4888465

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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