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Article

Transglutaminase 2 regulates the GTPase-activating activity of Bcr.

The Journal of biological chemistry - 18 Dec 2009

Yi Sun-Ju, Groffen John, Heisterkamp Nora

Abstract excerpt

Transglutaminase 2 (TG2) is a multifunctional protein that has been implicated in numerous pathologies including that of neurodegeneration and celiac disease, but the molecular interactions that mediate its diverse activities are largely unknown. Bcr and the closely related Abr negatively regulate the small G-protein Rac: loss of their combined function in vivo results in increased reactivity of innate immune...

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Identifiers

PMID: 19840940
DOI: 10.1074/jbc.M109.062240
PMCID: PMC2790995

Genes

EGF

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