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Article

IDH Mutation Analysis in Glioma Patients by CADMA Compared with SNaPshot Assay and two Immunohistochemical Methods.

Pathology oncology research : POR - 1 Jul 2019

Urbanovska Irena, Megova Magdalena Houdova, Dwight Zachary, Kalita Ondrej, Uvirova Magdalena, Simova Jarmila, Tuckova Lucie, Buzrla Petr, Palecek Tomas, Hajduch Marian, Dvorackova Jana, Drabek Jiri

Abstract excerpt

Mutations in IDH1/2 genes are a marker of good prognosis for glioma patients, associated with low grade gliomas and secondary glioblastomas. Immunohistochemistry and Sanger sequencing are current standards for IDH1/2 genotyping while many other methods exist. The aim of this study was to validate Competitive amplification of differentially melting amplicons (CADMA) PCR for IDH genotyping by comparison with...

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Identifiers

PMID: 29556922
DOI: 10.1007/s12253-018-0413-9
PMCID: PMC6614140

Genes

IDH1
IDH2

Variants

Provenance

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