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Article

Prospective, high-throughput molecular profiling of human gliomas.

Journal of neuro-oncology - 1 Oct 2012

Chi Andrew S, Batchelor Tracy T, Dias-Santagata Dora, Borger Darrell, Stiles Charles D, Wang Daphne L, Curry William T, Wen Patrick Y, Ligon Keith L, Ellisen Leif, Louis David N, Iafrate A John

Abstract excerpt

Gliomas consist of multiple histologic and molecular subtypes with different clinical phenotypes and responsiveness to treatment. However, enrollment criteria for clinical trials still largely do not take into account these underlying molecular differences. We have incorporated a high-throughput tumor genotyping program based on the ABI SNaPshot platform as well as other molecular diagnostic tests into the...

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Identifiers

PMID: 22821383
DOI: 10.1007/s11060-012-0938-9
PMCID: PMC3583376

Genes

EGFR
AKT1
BRAF
IDH1
KRAS
MET
MGMT
PDGFRA

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