Article
Upregulation of Mitimere and Nubbin acts through cyclin E to confer self-renewing asymmetric division potential to neural precursor cells.
Development (Cambridge, England) - 1 Mar 2004
Bhat Krishna Moorthi, Apsel Nora
Abstract excerpt
In the Drosophila CNS, neuroblasts undergo self-renewing asymmetric divisions, whereas their progeny, ganglion mother cells (GMCs), divide asymmetrically to generate terminal postmitotic neurons. It is not known whether GMCs have the potential to undergo self-renewing asymmetric divisions. It is also not known how precursor cells undergo self-renewing asymmetric divisions. Here, we report that maintaining high...
Topics
- Animals
- Animals, Genetically Modified
- Body Patterning
- Cell Division
- Cyclin E
- Drosophila
- Drosophila Proteins
- Gene Expression Regulation, Developmental
- Genes, Insect
- Homeodomain Proteins
- Mutation