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Article

Gcm protein degradation suppresses proliferation of glial progenitors.

Proceedings of the National Academy of Sciences of the United States of America - 21 Apr 2009

Ho Margaret Su-chun, Chen Hungwen, Chen Minghan, Jacques Cécile, Giangrande Angela, Chien Cheng-Ting

Abstract excerpt

Gliogenesis in animal development is spatiotemporally regulated so that correct numbers of glia are present to support various neuronal functions. During Drosophila embryonic development, the glial regulatory gene, glial cell missing/glial cell deficient (gcm/glide), promotes glial cell fate and differentiation. Here we describe the ubiquitin-proteasome regulation of the Gcm protein and the consequence in...

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Identifiers

PMID: 19346490
DOI: 10.1073/pnas.0808899106
PMCID: PMC2672493

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Source receipt: pubmed, retrieved 7 Sept 2026.

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