Normal function of the mushroom body defect gene of Drosophila is required for the regulation of the number and proliferation of neuroblasts.

Abstract excerpt

In the developing central nervous system of Drosophila, proliferation follows a reproducible and well-described spatial and temporal pattern. This pattern involves a defined number and distribution of neural stem cells (neuroblasts), as well as a precisely regulated time course of division of these neuroblasts. We show that mutations in the mushroom body defect (mud) gene interfere with the regulation of this...

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