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Article

Functional dissection of the Drosophila enhancer of split protein, a suppressor of neurogenesis.

Proceedings of the National Academy of Sciences of the United States of America - 10 Jun 1997

Giebel B, Campos-Ortega J A

Abstract excerpt

The Enhancer of split [E(spl)] gene complex of Drosophila comprises seven related genes encoding a special type of basic helix-loop-helix proteins, the function of which is to suppress the neural developmental fate. One of these proteins is E(spl) itself. To gain insight into the structural requirements for E(spl) function, we have expressed a large number of deletion variants in transgenic flies. Three protein...

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Identifiers

PMID: 9177203
DOI: 10.1073/pnas.94.12.6250
PMCID: PMC21035

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Functional dissection of the Drosophila enhancer of split protein, a suppressor of neurogenesis.PMID 9177203Read ↗

Enhancer of splitD, a dominant mutation of Drosophila, and its use in the study of functional domains of a helix-loop-helix protein.Semantic proximity Read ↗

A chimeric enhancer-of-split transcriptional activator drives neural development and achaete-scute expression.Semantic proximity Read ↗

Persistent expression of genes of the enhancer of split complex suppresses neural development in Drosophila.Semantic proximity Read ↗

Enhancer of split [E(spl)(D)] is a gro-independent, hypermorphic mutation in Drosophila.Semantic proximity Read ↗

Two genetically and molecularly distinct functions involved in early neurogenesis reside within the Enhancer of split locus of Drosophila melanogaster.Semantic proximity Read ↗

Functional relationships between Notch, Su(H) and the bHLH genes of the E(spl) complex: the E(spl) genes mediate only a subset of Notch activities during imaginal development.Semantic proximity Read ↗

Neurogenic phenotypes induced by RNA interference with bHLH genes of the Enhancer of split complex of Drosophila melanogaster.Semantic proximity Read ↗

Deletion mapping in the Enhancer of split complex.Semantic proximity Read ↗

The Enhancer of split complex and adjacent genes in the 96F region of Drosophila melanogaster are required for segregation of neural and epidermal progenitor cells.Semantic proximity Read ↗

The K box, a conserved 3' UTR sequence motif, negatively regulates accumulation of enhancer of split complex transcripts.Semantic proximity Read ↗

Specificity for the hairy/enhancer of split basic helix-loop-helix (bHLH) proteins maps outside the bHLH domain and suggests two separable modes of transcriptional repression.Semantic proximity Read ↗

Inhibition of cell fate in Drosophila by Enhancer of split genes.Semantic proximity Read ↗

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