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Article

Predicting the Mutating Distribution at Antigenic Sites of the Influenza Virus.

Scientific reports - 3 Feb 2016

Xu Hongyang, Yang Yiyan, Wang Shuning, Zhu Ruixin, Qiu Tianyi, Qiu Jingxuan, Zhang Qingchen, Jin Li, He Yungang, Tang Kailin, Cao Zhiwei

Abstract excerpt

Mutations of the influenza virus lead to antigenic changes that cause recurrent epidemics and vaccine resistance. Preventive measures would benefit greatly from the ability to predict the potential distribution of new antigenic sites in future strains. By leveraging the extensive historical records of HA sequences for 90 years, we designed a computational model to simulate the dynamic evolution of antigenic sites...

Topics

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Antigens, Viral
Computer Simulation
Evolution, Molecular
Influenza A Virus, H1N1 Subtype
Influenza A Virus, H3N2 Subtype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Influenza, Human

Models, Genetic

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Identifiers

PMID: 26837263
DOI: 10.1038/srep20239
PMCID: PMC4738307

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