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Article

Negative feedback confers mutational robustness in yeast transcription factor regulation.

Proceedings of the National Academy of Sciences of the United States of America - 6 Mar 2012

Denby Charles M, Im Joo Hyun, Yu Richard C, Pesce C Gustavo, Brem Rachel B

Abstract excerpt

Organismal fitness depends on the ability of gene networks to function robustly in the face of environmental and genetic perturbations. Understanding the mechanisms of this stability is one of the key aims of modern systems biology. Dissecting the basis of robustness to mutation has proven a part...

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Identifiers

PMID: 22355134
DOI: 10.1073/pnas.1116360109
PMCID: PMC3309721

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22355134-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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